Spinal and non-spinal injections form the basis of interventional pain management. By precisely placing a variety of medications or substances into a joint space or nerve bundle, pain management physicians can treat and diagnose a wide variety of chronic pain conditions. These minimally invasive procedures can be used to treat chronic low back pain, chronic neck pain, malignancies, nerve damage and numerous other related pain disorders. Pain management injections provide an alternative treatment for patients who have tried other modalities with little or no success. These procedures often improve function, and allow patients to return to their everyday lives while potentially minimizing the need for powerful daily medications. Medications used in pain management injections can include corticosteroids, and proliferative ozone (prolo-ozone).